Asia Pac ECM and Index Rebal, Shenton Research

Ke Yan, CFA, FRM

Asia Pac ECM and Index Rebal

Asia Pac IPO & Placement Research, China Biotech

DZT Research

DZT Research is an independent Asia Pacific equity specialist. Our quantitative research covers index rebalancing flows, alongside exchange data analytics accross Asia Pacific. On the equity capital markets side, we focus on Asia Pacific ECM, especially biotech and TMT. Our lead analyst is frequently cited by international media.

Equity Capital Markets

Zhaoke Ophthalmology / Equity Capital Markets

<p>Founded by Lee's Pharma, Zhaoke offers a comprehensive ophthalmic product pipeline. The company launched book building to raise up to USD 267m via a Hong Kong listing.</p><p>In our previous note, we looked at the company's two products, namely CsA gel and ZKY001. We are of the view that CsA gel does provide advantage over Restasis, the top selling eye gel for the DED, but the forecast of market growth is too aggressive for the DED market. For another core product ZKY001, while there is no data on the efficacy from Phase I clinical trial, we do note that the licensing parnter's product which uses the same technology but on a different indication, did not meet the primary end point in Phase III clinical trial according to a recent announcement, which raises our concern on the potential of the product candidate. In addition, the company also had a long list of generic referencing top selling glaucoma drugs. The company has an OK management team but strong backing of institutional investors.  </p><p>We think the valuation is rich at the high end and the cornerstone investors' commitment left a large portion of the deal to be sold on debut. We also note that the market sentiment is not very positive on the ophthalmic deals.</p><div><div><h2>Our previous coverage on Zhaoke Ophthalmic</h2></div></div><div><ul style="list-style-type: disc;">
<li><a href="https://www.smartkarma.com/insights/zhaoke-ophthalmic-could-be-over-valued-for-pre-ipo-round" target="_blank" rel="noopener">Zhaoke Ophthalmic (兆科眼科): Could Be Over-Valued for Pre-IPO Round</a></li>
<li><a href="https://www.smartkarma.com/insights/zhaoke-ophthalmic-pre-ipo-thoughts-on-valuation" target="_blank" rel="noopener">Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Thoughts on Valuation</a></li>
<li><a href="https://www.smartkarma.com/insights/zhaoke-ophthalmic-pre-ipo-beware-of-aggressive-guidance" target="_blank" rel="noopener">Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Beware of Aggressive “Guidance”</a></li>
</ul></div>

Founded by Lee's Pharma, Zhaoke offers a comprehensive ophthalmic product pipeline. The company launched book building to raise up to USD 267m via a Hong Kong listing.In our previous note, we looked at the company's two products, namely CsA gel and ZKY001. We are of the view that CsA gel does provide advantage over Restasis, the top selling eye gel for the DED, but the forecast of market growth is too aggressive for the DED market. For another core product ZKY001, while there is no data on the efficacy from Phase I clinical trial, we do note that the licensing parnter's product which uses the same technology but on a different indication, did not meet the primary end point in Phase III clinical trial according to a recent announcement, which raises our concern on the potential of the product candidate. In addition, the company also had a long list of generic referencing top selling glaucoma drugs. The company has an OK management team but strong backing of institutional investors.  We think the valuation is rich at the high end and the cornerstone investors' commitment left a large portion of the deal to be sold on debut. We also note that the market sentiment is not very positive on the ophthalmic deals.Our previous coverage on Zhaoke Ophthalmic
Zhaoke Ophthalmic (兆科眼科): Could Be Over-Valued for Pre-IPO Round
Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Thoughts on Valuation
Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Beware of Aggressive “Guidance”


Zhaoke Ophthalmic (兆科眼科) IPO: Rationalize the Valuation

<div>
<p>Founded by Lee's Pharma, Zhaoke offers a comprehensive ophthalmic product pipeline. The company is looking to raise up to USD 200m via a Hong Kong listing.</p>
</div>
<div>
<p>In our previous note, we looked at the company's two products, namely CsA gel and ZKY001. We are of the view that CsA gel does provide advantage over Restasis, the top selling eye gel for the DED, but the forecast of market growth is too aggressive for the DED market. For another core product ZKY001, while there is no data on the efficacy from Phase I clinical trial, we do note that the licensing parnter's product which uses the same technology but on a different indication, did not meet the primary end point in Phase III clinical trial according to a recent announcement, which raises our concern on the potential of the product candidate. In addition, the company also had a long list of generic referencing top selling glaucoma drugs. The company has an OK management team but strong backing of institutional investors.  We have also provided a preliminary valuation for its core products. </p>
<p>We did research on its key competitor in the CsA segment, namely Sinqi, which is listed on the A-share market with a ticker 300573 CH. Sinqi has recently planned to place shares to fund the expansion of the manufacturing facility for the CsA product which was approved by the NMPA in June 2020. From its disclosure, we can see that the CsA market could be aggressively overstated by the third-party consultant Frost &amp; Sullivan who provided the market forecast for the company's prospectus.</p>
</div>
<div>
<h2>Our previous coverage on Zhaoke Ophthalmic</h2>
</div>
<div>
<ul style="list-style-type: disc;">
<li><a href="https://www.smartkarma.com/insights/zhaoke-ophthalmic-could-be-over-valued-for-pre-ipo-round" target="_blank" rel="noopener">Zhaoke Ophthalmic (兆科眼科): Could Be Over-Valued for Pre-IPO Round</a></li>
<li><a href="https://www.smartkarma.com/insights/zhaoke-ophthalmic-pre-ipo-thoughts-on-valuation" target="_blank" rel="noopener">Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Thoughts on Valuation</a></li>
</ul>
</div>


Founded by Lee's Pharma, Zhaoke offers a comprehensive ophthalmic product pipeline. The company is looking to raise up to USD 200m via a Hong Kong listing.


In our previous note, we looked at the company's two products, namely CsA gel and ZKY001. We are of the view that CsA gel does provide advantage over Restasis, the top selling eye gel for the DED, but the forecast of market growth is too aggressive for the DED market. For another core product ZKY001, while there is no data on the efficacy from Phase I clinical trial, we do note that the licensing parnter's product which uses the same technology but on a different indication, did not meet the primary end point in Phase III clinical trial according to a recent announcement, which raises our concern on the potential of the product candidate. In addition, the company also had a long list of generic referencing top selling glaucoma drugs. The company has an OK management team but strong backing of institutional investors.  We have also provided a preliminary valuation for its core products. 
We did research on its key competitor in the CsA segment, namely Sinqi, which is listed on the A-share market with a ticker 300573 CH. Sinqi has recently planned to place shares to fund the expansion of the manufacturing facility for the CsA product which was approved by the NMPA in June 2020. From its disclosure, we can see that the CsA market could be aggressively overstated by the third-party consultant Frost &amp; Sullivan who provided the market forecast for the company's prospectus.


Our previous coverage on Zhaoke Ophthalmic



Zhaoke Ophthalmic (兆科眼科): Could Be Over-Valued for Pre-IPO Round
Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Thoughts on Valuation



Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Beware of Aggressive "Guidance"

Equity Analyst, LightStream Research

Shifara Samsudeen, FCMA, CGMA

Equity Analyst

Long-Short Analysis on Japan, Asia and the World

LightStream Research

LightStream conducts quantitatively rigorous and data-driven analysis with a focus on Japan and Asia.

We consistently cover the Tech, Consumer and Industrial sectors, and provide ECM and Events coverage more broadly.

We supplement traditional qualitative insights from company relationships with a robust quantitative foundation that examines as much historical data as is available.
We further refine the accuracy of our insights and calls through the use of alternative data to flesh out current trends, and through a valuation framework that emphasises non-superficial peer group selection and a proper attempt to understand the metrics and changes that have driven security valuations in the past.

<p><a href="https://www.smartkarma.com/entities/zhaoke-ophthalmology-pharmaceutical" target="_blank" data-smartkarma-citation="entities:31495:1" rel="noopener">Zhaoke Ophthalmology Pharmaceutical (ZKO HK)</a>  is an ophthalmic pharmaceutical company in China dedicated to the research and development and commercialisation of therapies. The company has an ophthalmic drug pipeline of 25 candidates that covers most major ocular indications that affect the front and the back of the eye either through in-house development or in-licensing. According to CIC, the company has one of the most comprehensive ophthalmic drug pipelines in China.</p><p>Zhaoke has filed for an IPO to list its shares on the Hong Kong Stock Exchange and plans to raise proceeds of about US$200m through the IPO.</p><p>The company currently does not have any products approved for commercial sale; hence the company does not generate any revenues from product sales. However, the company’s drug development pipeline includes a few late stage drug candidates that have the potential to become market-leading products.</p>

Zhaoke Ophthalmology Pharmaceutical (ZKO HK)  is an ophthalmic pharmaceutical company in China dedicated to the research and development and commercialisation of therapies. The company has an ophthalmic drug pipeline of 25 candidates that covers most major ocular indications that affect the front and the back of the eye either through in-house development or in-licensing. According to CIC, the company has one of the most comprehensive ophthalmic drug pipelines in China.Zhaoke has filed for an IPO to list its shares on the Hong Kong Stock Exchange and plans to raise proceeds of about US$200m through the IPO.The company currently does not have any products approved for commercial sale; hence the company does not generate any revenues from product sales. However, the company’s drug development pipeline includes a few late stage drug candidates that have the potential to become market-leading products.

Zhaoke Opthalmology IPO: Promising Drug Candidates; but Commercialisation May Take Longer

IPOs and Catalysts/Events, Global Equity Research Ltd

Arun George

IPOs and Catalysts/Events

Uncompromised, Independent, Conflict-Free Research

Global Equity Research Ltd

Global Equity Research was started in 2017 by a group of experienced research professionals. It was founded on a passionate belief in the importance and the need for uncompromised, independent, conflict-free research. We aim to provide differentiated and actionable primary and bottom up fundamental research.

<p><a href="https://www.smartkarma.com/entities/zhaoke-ophthalmology-pharmaceutical" target="_blank" data-smartkarma-citation="entities:31495:1" rel="noopener">Zhaoke Ophthalmology Pharmaceutical (ZKO HK)</a> is an ophthalmic pharma company that has an ophthalmic drug pipeline of 13 innovative drugs and 12 generic drugs. Zhaoke has one of the most comprehensive ophthalmic drug pipelines in China, according to CIC. Zhaoke was founded by <a href="https://www.smartkarma.com/entities/lee-s-pharmaceutical-hldgs" target="_blank" data-smartkarma-citation="entities:14616:1" rel="noopener">Lee's Pharmaceutical (950 HK)</a> which is the largest shareholder. Zhaoke’s other shareholders include GIC, Hillhouse, TPG, Loyal Valley Capital, Orbimed and Aier Eye Hospital. </p><div class="content-highlight"><p>Zhaoke is pre-marketing an HKEx IPO to raise $200 million, according to press reports. The pipeline includes 8 drug candidates which have the potential to be market-leading products in China. The generic pipeline includes 6 potential first-to-market generics in China. Overall, we believe that Zhaoke’s drug assets are attractive. </p></div>

Zhaoke Ophthalmology Pharmaceutical (ZKO HK) is an ophthalmic pharma company that has an ophthalmic drug pipeline of 13 innovative drugs and 12 generic drugs. Zhaoke has one of the most comprehensive ophthalmic drug pipelines in China, according to CIC. Zhaoke was founded by Lee's Pharmaceutical (950 HK) which is the largest shareholder. Zhaoke’s other shareholders include GIC, Hillhouse, TPG, Loyal Valley Capital, Orbimed and Aier Eye Hospital. Zhaoke is pre-marketing an HKEx IPO to raise $200 million, according to press reports. The pipeline includes 8 drug candidates which have the potential to be market-leading products in China. The generic pipeline includes 6 potential first-to-market generics in China. Overall, we believe that Zhaoke’s drug assets are attractive. 

Zhaoke Ophthalmology IPO Initiation: The Eyes Have It

<p>Founded by Lee's Pharma, Zhaoke offers a comprehensive ophthalmic product pipeline. The company is looking to raise up to USD 200m via a Hong Kong listing.</p><p>In our previous note, we looked at the company's two products, namely CsA gel and ZKY001. We are of the view that CsA gel does provide advantage over Restasis, the top selling eye gel for the DED, but the forecast of market growth is too aggressive for the DED market. For another core product ZKY001, while there is no data on the efficacy from Phase I clinical trial, we do note that the licensing parnter's product which uses the same technology but on a different indication, did not meet the primary end point in Phase III clinical trial according to a recent announcement, which raises our concern on the potential of the product candidate. In addition, the company also had a long list of generic referencing top selling glaucoma drugs. The company has an OK management team but strong backing of institutional investors.  </p><p>In this note, we provide a forecast on the company's two core products CsA gel and the ZKY001. </p><h2>Our previous coverage on Zhaoke Ophthalmic</h2><ul><li><a href="https://www.smartkarma.com/insights/zhaoke-ophthalmic-could-be-over-valued-for-pre-ipo-round" target="_blank" rel="noopener">Zhaoke Ophthalmic (兆科眼科): Could Be Over-Valued for Pre-IPO Round</a></li></ul>

Founded by Lee's Pharma, Zhaoke offers a comprehensive ophthalmic product pipeline. The company is looking to raise up to USD 200m via a Hong Kong listing.In our previous note, we looked at the company's two products, namely CsA gel and ZKY001. We are of the view that CsA gel does provide advantage over Restasis, the top selling eye gel for the DED, but the forecast of market growth is too aggressive for the DED market. For another core product ZKY001, while there is no data on the efficacy from Phase I clinical trial, we do note that the licensing parnter's product which uses the same technology but on a different indication, did not meet the primary end point in Phase III clinical trial according to a recent announcement, which raises our concern on the potential of the product candidate. In addition, the company also had a long list of generic referencing top selling glaucoma drugs. The company has an OK management team but strong backing of institutional investors.  In this note, we provide a forecast on the company's two core products CsA gel and the ZKY001. Our previous coverage on Zhaoke OphthalmicZhaoke Ophthalmic (兆科眼科): Could Be Over-Valued for Pre-IPO Round

Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Thoughts on Valuation

China

Zhaoke Ophthalmology is an ophthalmic pharmaceutical company focused on the research, development, manufacturing, and commercialization of therapies for unmet medical needs in eye diseases. Its comprehensive drug portfolio addresses conditions such as dry eye disease, myopia, presbyopia, wet age-related macular degeneration, diabetic macular edema, and glaucoma. The company was founded in 2017 and is headquartered in Guangzhou, China.

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Zhaoke Ophthalmology (6622 HK)

Zhaoke Ophthalmic (兆科眼科) IPO: Rationalize the Valuation

We think the valuation is rich at the high end and the cornerstone investors' commitment left a large portion of the deal to be sold on debut.

Ke Yan, CFA, FRM

Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Beware of Aggressive "Guidance"

We did research on its key competitor in the CsA segment and think that Frost & Sullivan grossly underestimates the competition and overestimates...

Ke Yan, CFA, FRM

Zhaoke Opthalmology IPO: Promising Drug Candidates; but Commercialisation May Take Longer

Zhaoke's strong drug pipeline demonstrates strong growth potential and some of the company’s drug candidates have the potential to become market...

Shifara Samsudeen, FCMA, CGMA

Zhaoke Ophthalmology IPO Initiation: The Eyes Have It

Zhaoke is pre-marketing an HKEx IPO to raise $200 million, according to press reports. Overall, we believe that Zhaoke’s drug assets are attractive.

Arun George

Zhaoke Ophthalmic (兆科眼科) Pre-IPO: Thoughts on Valuation

In this note, we provide a forecast on Zhaoke Ophthalmic's two core products CsA ophthalmic gel and the ZKY001 and an SOTP based valuation for the...

Ke Yan, CFA, FRM

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