External broker reports(aggregated public sources), CMB International

CMB International

Incorporated in Hong Kong, supported by the mainland and targeting in global market, CMB International Capital Corporation Limited (“CMBI”) is an integrated financial institution providing comprehensive and professional services. As a wholly-owned subsidiary of China Merchants Bank ("CMB"), by leveraging on the Group’s synergy and coordination in domestic and overseas markets, as well as CMB’s strong resources and outstanding social reputation, CMBI and its subsidiaries have been actively implementing diversified business strategies and set up an overall layout of main business segments including Corporate Finance, Asset Management, Wealth Management, Global Markets and Structured Finance, etc. Adhering to the philosophy of “being clients oriented and increasing our own values by the way of creating value for clients”, CMBI endeavors to provide quality and integrated financial services to institutional, corporate and individual customers both domestic and overseas including Hong Kong IPO sponsorship and underwriting, share placement and rights issue for listed companies, financial advisors, bonds issuance services, asset management, direct investment, wealth management, equity sales and trading, etc.

External broker reports(aggregated public sources)

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<ul><li>CDK4i demonstrated favourable hematologic safety with reduced neutropenia.</li><li>BeOne’s CDK4 inhibitor (BGB-43395) shows a favorable hematologic safety profile, supported by improved CDK4/CDK6 selectivity that reduces off-target and CDK6-mediated toxicities.</li><li>In dose optimization cohorts (n=61), grade ≥3 TRAEs occurred in only 19.7% of pre-treated breast cancer and solid tumor patients receiving BGB-43395 (240–600 mg BID) plus fulvestrant. </li></ul><p><em>Content is external broker report sourced from online content aggregator through publicly available sources and is displayed below for general informational purposes only. Refer full disclaimer below.</em></p>

CDK4i demonstrated favourable hematologic safety with reduced neutropenia.BeOne’s CDK4 inhibitor (BGB-43395) shows a favorable hematologic safety profile, supported by improved CDK4/CDK6 selectivity that reduces off-target and CDK6-mediated toxicities.In dose optimization cohorts (n=61), grade ≥3 TRAEs occurred in only 19.7% of pre-treated breast cancer and solid tumor patients receiving BGB-43395 (240–600 mg BID) plus fulvestrant. Content is external broker report sourced from online content aggregator through publicly available sources and is displayed below for general informational purposes only. Refer full disclaimer below.

BeiGene (ONC US) - CDK4i Showed Preliminary Efficacy While Data Still Maturing